Blomstrand, Berit Marie; Thamsborg, Stig Milan; Steinshamn, Håvard; Enemark, Heidi L.; Aasen, Inga Marie; Mahnert, Karl-Christian; Sørheim, Kristin Marie; Shepherd, Francesca; Houdijk, J.G.M. and Athanasiadou, Spiridoula (2025) Pinus sylvestris bark extract reduces the impact of Heligmosomoides bakeri infection on C57BL/6 but not on BALB/c mice (Mus musculus). Parasitology, 1, pp. 1-9.
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Document available online at: https://www.cambridge.org/core/journals/parasitology/article/pinus-sylvestris-bark-extract-reduces-the-impact-of-heligmosomoides-bakeri-infection-on-c57bl6-but-not-on-balbc-mice-mus-musculus/7F977B18C5B19D906535D947D96DF759
Summary in the original language of the document
Plant secondary metabolites (PSMs) may improve gastrointestinal health by exerting immunomodulatory, anti-inflammatory and/or antiparasitic effects. Bark extracts from coniferous tree species have previously been shown to reduce the burden of a range of parasite species in the gastrointestinal tract, with condensed tannins as the potential active compounds. In the present study, the impact of an acetone extract of pine bark (Pinus sylvestris) on the resistance, performance and tolerance of genetically diverse mice (Mus musculus) was assessed. Mice able to clear an infection quickly (fast responders, BALB/c) or slowly (slow responders, C57BL/6) were infected orally with 200 infective third-stage larvae (L3) of the parasitic nematode Heligmosomoides bakeri or remained uninfected (dosed with water only). Each infection group of mice was gavaged for 3 consecutive days from day 19 post-infection with either bark extract or dimethyl sulphoxide (5%) as vehicle control. Oral administration of pine bark extract did not have an impact on any of the measured parasitological parameter. It did, however, have a positive impact on the performance of infected, slow-responder mice, through an increase in body weight (BW) and carcase weight and reduced feed intake by BW ratio. Importantly, bark extract administration had a negative impact on the fast responders, by reducing their ability to mediate the impact of parasitism through reducing their performance and tolerance. The results indicate that the impact of PSMs on parasitized hosts is affected by host's genetic susceptibility, with susceptible hosts benefiting more from bark extract administration compared to resistant ones.
EPrint Type: | Journal paper |
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Keywords: | BarkCure |
Agrovoc keywords: | Language Value URI English bark extracts http://aims.fao.org/aos/agrovoc/c_35304 English tannins http://aims.fao.org/aos/agrovoc/c_7606 English gastrointestinal diseases http://aims.fao.org/aos/agrovoc/c_11105 English nematodes http://aims.fao.org/aos/agrovoc/c_47faeccc English resistance to parasites -> parasite resistance http://aims.fao.org/aos/agrovoc/c_17971197 English tolerance to diseases -> disease tolerance http://aims.fao.org/aos/agrovoc/c_331441 English Heligmosomoides http://aims.fao.org/aos/agrovoc/c_26516 English mice http://aims.fao.org/aos/agrovoc/c_4795 |
Subjects: | Animal husbandry > Health and welfare |
Research affiliation: | Denmark > KU - University of Copenhagen Norway > NIBIO – Norwegian Institute of Bioeconomy Research Norway > SINTEF Norway > NORSØK - Norwegian Centre for Organic Agriculture UK > Scottish Rural Colleges (SRUC - previously SAC) Norway > Other organizations Norway |
DOI: | 10.1017/S0031182024001148 |
Deposited By: | Blomstrand, Dr Berit Marie |
ID Code: | 54605 |
Deposited On: | 29 Jan 2025 09:11 |
Last Modified: | 29 Jan 2025 09:11 |
Document Language: | English |
Status: | Published |
Refereed: | Peer-reviewed and accepted |
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