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Pinus sylvestris bark extract reduces the impact of Heligmosomoides bakeri infection on C57BL/6 but not on BALB/c mice (Mus musculus)

Blomstrand, Berit Marie; Thamsborg, Stig Milan; Steinshamn, Håvard; Enemark, Heidi L.; Aasen, Inga Marie; Mahnert, Karl-Christian; Sørheim, Kristin Marie; Shepherd, Francesca; Houdijk, J.G.M. and Athanasiadou, Spiridoula (2025) Pinus sylvestris bark extract reduces the impact of Heligmosomoides bakeri infection on C57BL/6 but not on BALB/c mice (Mus musculus). Parasitology, 1, pp. 1-9.

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Document available online at: https://www.cambridge.org/core/journals/parasitology/article/pinus-sylvestris-bark-extract-reduces-the-impact-of-heligmosomoides-bakeri-infection-on-c57bl6-but-not-on-balbc-mice-mus-musculus/7F977B18C5B19D906535D947D96DF759


Summary in the original language of the document

Plant secondary metabolites (PSMs) may improve gastrointestinal health by exerting immunomodulatory, anti-inflammatory and/or antiparasitic effects. Bark extracts from coniferous tree species have previously been shown to reduce the burden of a range of parasite species in the gastrointestinal tract, with condensed tannins as the potential active compounds. In the present study, the impact of an acetone extract of pine bark (Pinus sylvestris) on the resistance, performance and tolerance of genetically diverse mice (Mus musculus) was assessed. Mice able to clear an infection quickly (fast responders, BALB/c) or slowly (slow responders, C57BL/6) were infected orally with 200 infective third-stage larvae (L3) of the parasitic nematode Heligmosomoides bakeri or remained uninfected (dosed with water only). Each infection group of mice was gavaged for 3 consecutive days from day 19 post-infection with either bark extract or dimethyl sulphoxide (5%) as vehicle control. Oral administration of pine bark extract did not have an impact on any of the measured parasitological parameter. It did, however, have a positive impact on the performance of infected, slow-responder mice, through an increase in body weight (BW) and carcase weight and reduced feed intake by BW ratio. Importantly, bark extract administration had a negative impact on the fast responders, by reducing their ability to mediate the impact of parasitism through reducing their performance and tolerance. The results indicate that the impact of PSMs on parasitized hosts is affected by host's genetic susceptibility, with susceptible hosts benefiting more from bark extract administration compared to resistant ones.


EPrint Type:Journal paper
Keywords:BarkCure
Agrovoc keywords:
Language
Value
URI
English
bark extracts
http://aims.fao.org/aos/agrovoc/c_35304
English
tannins
http://aims.fao.org/aos/agrovoc/c_7606
English
gastrointestinal diseases
http://aims.fao.org/aos/agrovoc/c_11105
English
nematodes
http://aims.fao.org/aos/agrovoc/c_47faeccc
English
resistance to parasites -> parasite resistance
http://aims.fao.org/aos/agrovoc/c_17971197
English
tolerance to diseases -> disease tolerance
http://aims.fao.org/aos/agrovoc/c_331441
English
Heligmosomoides
http://aims.fao.org/aos/agrovoc/c_26516
English
mice
http://aims.fao.org/aos/agrovoc/c_4795
Subjects: Animal husbandry > Health and welfare
Research affiliation: Denmark > KU - University of Copenhagen
Norway > NIBIO – Norwegian Institute of Bioeconomy Research
Norway > SINTEF
Norway > NORSØK - Norwegian Centre for Organic Agriculture
UK > Scottish Rural Colleges (SRUC - previously SAC)
Norway > Other organizations Norway
DOI:10.1017/S0031182024001148
Deposited By: Blomstrand, Dr Berit Marie
ID Code:54605
Deposited On:29 Jan 2025 09:11
Last Modified:29 Jan 2025 09:11
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted

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