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Whole-Genome Sequencing Data Reveal New Loci Affecting Milk Production in German Black Pied Cattle (DSN)

Korkuc, Paula; Neumann, Guilherme B.; Hesse, Deike; Arends, Danny; Reißmann, Monika; Rahmatalla, Siham; May, Katharina; Wolf, Manuel J.; König, Sven and Brockmann, Gudrun A. (2023) Whole-Genome Sequencing Data Reveal New Loci Affecting Milk Production in German Black Pied Cattle (DSN). Genes, 14 (581), pp. 1-18.

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Document available online at: https://pubmed.ncbi.nlm.nih.gov/36980854/


Summary

German Black Pied (DSN) is considered an ancestral population of the Holstein breed. The goal of the current study was to fine-map genomic loci for milk production traits and to provide sequence variants for selection. We studied genome-wide associations for milk-production traits in 2160 DSN cows. Using 11.7 million variants from whole-genome sequencing of 304 representative DSN cattle, we identified 1980 associated variants (-log10(p)> 7.1) in 13 genomic loci on 9 chromosomes. The highest significance was found for the MGST1 region affecting milk fat content (-log10(p) = 11.93, MAF = 0.23, substitution effect of the minor allele (ßMA) = -0.151%). Different from Holstein, DGAT1 was fixed (0.97) for the alanine protein variant for high milk and protein yield. A key gene affecting protein content was CSN1S1 (-log10(p) = 8.47, MAF = 049, ßMA = -0.055%) and the GNG2 region (-log10(p) = 10.48, MAF = 0.34, ßMA = 0.054%). Additionally, we suggest the importance of FGF12 for protein and fat yield, HTR3C for milk yield, TLE4 for milk and protein yield, and TNKS for milk and fat yield. Selection for favored alleles can improve milk yield and composition. With respect to maintaining the dual-purpose type of DSN, unfavored linkage to genes affecting muscularity has to be investigated carefully, before the milk-associated variants can be applied for selection in the small population.


EPrint Type:Journal paper
Type of presentation:Paper
Keywords:BLE, BÖL, BOEL, FKZ 15NA010, DSN – Deutsches Schwarzbuntes Niederungsrind, Milchvieh, Doppelnutzungsr1nd, Genreserve, Erhaltungszucht, Genetische Marker, Milch
Agrovoc keywords:
Language
Value
URI
English
cattle
http://aims.fao.org/aos/agrovoc/c_1391
English
genotypes
http://aims.fao.org/aos/agrovoc/c_3225
English
genetic markers
http://aims.fao.org/aos/agrovoc/c_24030
Subjects: Animal husbandry > Production systems > Dairy cattle
Animal husbandry > Production systems > Beef cattle
Animal husbandry > Breeding and genetics
Research affiliation: Germany > Federal Organic Farming Scheme - BOEL > Animals > Tierzucht
Germany > University of Berlin - HU
Germany > University of Gießen > Institute of Animal Breeding and Genetics
UK > Other organizations United Kingdom
DOI:10.3390/ genes14030581
Related Links:https://www.bundesprogramm.de, https://orgprints.org/id/eprint/30261/, https://www.ble.de/DE/Projektfoerderung/projektfoerderung_node.html
Deposited By: Korkuc, Dr. Paula
ID Code:52433
Deposited On:18 Jan 2024 08:46
Last Modified:19 Jan 2024 13:56
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted
Additional Publishing Information:Gefördert durch das Bundesministerium für Ernährung und Landwirtschaft aufgrund eines Beschlusses des Deutschen Bundestages im Rahmen des Bundesprogramms Ökologischer Landbau und andere Formen nachhaltiger Landwirtschaft.

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