Korkuc, Paula; Neumann, Guilherme B.; Hesse, Deike; Arends, Danny; Reißmann, Monika; Rahmatalla, Siham; May, Katharina; Wolf, Manuel J.; König, Sven and Brockmann, Gudrun A. (2023) Whole-Genome Sequencing Data Reveal New Loci Affecting Milk Production in German Black Pied Cattle (DSN). Genes, 14 (581), pp. 1-18.
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Document available online at: https://pubmed.ncbi.nlm.nih.gov/36980854/
Summary
German Black Pied (DSN) is considered an ancestral population of the Holstein breed. The goal of the current study was to fine-map genomic loci for milk production traits and to provide sequence variants for selection. We studied genome-wide associations for milk-production traits in 2160 DSN cows. Using 11.7 million variants from whole-genome sequencing of 304 representative DSN cattle, we identified 1980 associated variants (-log10(p)> 7.1) in 13 genomic loci on 9 chromosomes. The highest significance was found for the MGST1 region affecting milk fat content (-log10(p) = 11.93, MAF = 0.23, substitution effect of the minor allele (ßMA) = -0.151%). Different from Holstein, DGAT1 was fixed (0.97) for the alanine protein variant for high milk and protein yield. A key gene affecting protein content was CSN1S1 (-log10(p) = 8.47, MAF = 049, ßMA = -0.055%) and the GNG2 region (-log10(p) = 10.48, MAF = 0.34, ßMA = 0.054%). Additionally, we suggest the importance of FGF12 for protein and fat yield, HTR3C for milk yield, TLE4 for milk and protein yield, and TNKS for milk and fat yield. Selection for favored alleles can improve milk yield and composition. With respect to maintaining the dual-purpose type of DSN, unfavored linkage to genes affecting muscularity has to be investigated carefully, before the milk-associated variants can be applied for selection in the small population.
EPrint Type: | Journal paper |
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Type of presentation: | Paper |
Keywords: | BLE, BÖL, BOEL, FKZ 15NA010, DSN – Deutsches Schwarzbuntes Niederungsrind, Milchvieh, Doppelnutzungsr1nd, Genreserve, Erhaltungszucht, Genetische Marker, Milch |
Agrovoc keywords: | Language Value URI English cattle http://aims.fao.org/aos/agrovoc/c_1391 English genotypes http://aims.fao.org/aos/agrovoc/c_3225 English genetic markers http://aims.fao.org/aos/agrovoc/c_24030 |
Subjects: | Animal husbandry > Production systems > Dairy cattle Animal husbandry > Production systems > Beef cattle Animal husbandry > Breeding and genetics |
Research affiliation: | Germany > Federal Organic Farming Scheme - BOEL > Animals > Tierzucht Germany > University of Berlin - HU Germany > University of Gießen > Institute of Animal Breeding and Genetics UK > Other organizations United Kingdom |
DOI: | 10.3390/ genes14030581 |
Related Links: | https://www.bundesprogramm.de, https://orgprints.org/id/eprint/30261/, https://www.ble.de/DE/Projektfoerderung/projektfoerderung_node.html |
Deposited By: | Korkuc, Dr. Paula |
ID Code: | 52433 |
Deposited On: | 18 Jan 2024 08:46 |
Last Modified: | 19 Jan 2024 13:56 |
Document Language: | English |
Status: | Published |
Refereed: | Peer-reviewed and accepted |
Additional Publishing Information: | Gefördert durch das Bundesministerium für Ernährung und Landwirtschaft aufgrund eines Beschlusses des Deutschen Bundestages im Rahmen des Bundesprogramms Ökologischer Landbau und andere Formen nachhaltiger Landwirtschaft. |
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