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Natural product based anti-adhesion therapy- innovative prevention against bacterial infections

Toivanen, Marko; Huttunen, Sanna; Riihinen, Kaisu; Obey, Jackie and Tikkanen-Kaukanen, Carina (2017) Natural product based anti-adhesion therapy- innovative prevention against bacterial infections. In: Aakkula, Jyrki; Hakala, Kaija; Huhta, Harri; Iivonen, Sari; Jurvanen, Ulla; Kreismane, Dzidra; Land, Anita; Lähdesmäki, Merja; Malingen, Matti; Mikkola, Minna; Nordlund-Othen, Janne; Nuutila, Jaakko; Peetsmann, Elen; Piskonen, Sirpa; Rasmussen, Ilse A.; Skulskis, Virgilijus; Tahvonen, Raija; Taskinen, Sirpa; Ullvén, Karin; Wibe, Atle and Wivstad, Maria (Eds.) NJF Seminar 495 - 4th organic Conference: Organics for tomorrow's food systems, 19 - 21 June 2017, Mikkeli, Finland, 13 (1), NJF Report, pp. 96-98.

[thumbnail of Toivanen et al NJF17.docx] Microsoft Word - Accepted Version - English


Antimicrobial resistance (AMR) resistance, similar to climate change, is a shared global problem. AMR threatens the effective prevention and treatment of an ever-increasing range of infections. There are plenty of resistant bacteria that cause common infections such as urinary tract infections and pneumonia. In addition to causing death, disability and suffering AMR has huge economic impacts. The alarming increase in drug-resistant bacteria means that there is a need for novel means of fighting against bacterial infections. One feasible approach is to use agents that interfere with the ability of the bacteria to adhere to the tissues of the host, the initial stages of the infectious process. Our research project deals with milk oligosaccharides, wild berry and herbal bioactive polyphenols in prevention of bacterial attachment to human nasopharynx. We have focused on major human respiratory pathogenic bacteria. By employing several in vitro techniques we have shown that wild berry molecular fractions inhibit the binding of the serious human pathogen Neisseria meningitidis, associated with fatal invasive infections, meningitidis and septicemia. Anti-infective properties of wild berry fractions against different Streptococci causing human respiratory infections, newborn meningitis, animal diseases and associated with dental caries have been detected as well. Inhibitory activity of the berry material has been extracted especially from wild Vaccinium berries (bilberries, cranberries, and lingonberries) and from crowberries. Bioactive wild berry polyphenols represent organic products from wild forests subjected under organic certification.

EPrint Type:Conference paper, poster, etc.
Type of presentation:Paper
Keywords:antimicrobial resistance, bacterial adhesion, anti-adhesion therapy, berry, polyphenol, herb, anti-infective, infectious diseases, bacterial pathogens, respiratory infections
Subjects: Food systems > Food security, food quality and human health
Animal husbandry > Feeding and growth
Crop husbandry > Crop health, quality, protection
Research affiliation: International Conferences > 2017: NJF Seminar 495 - Organics for tomorrow's food systems > 2. Organic food, human health and wellbeing
Deposited By: Tikkanen-Kaukanen, AdjProf Carina
ID Code:31613
Deposited On:19 Jun 2017 09:12
Last Modified:19 Jun 2017 09:12
Document Language:English
Refereed:Peer-reviewed and accepted

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