Menoud, Valérie; Holinger, Mirjam; Graf-Schiller, Sandra; Mayer, Philipp; Gerber, Luc; Walkenhorst, Michael and Hirsbrunner, Gaby (2024) Comparison between intrauterine application of an antibiotic and an herbal product to treat clinical endometritis in dairy cattle – A randomized multicentre field study. Research in Veterinary Science, 172 (105250), pp. 1-9.
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Document available online at: https://www.sciencedirect.com/science/article/abs/pii/S0034528824001164
Summary in the original language of the document
Uterine diseases are main indications for antibiotic use in dairy cows. To test a non-antibiotic treatment option, we compared the effect of an intrauterine cephapirin (Metricure®; cefapirin benzathin 500 mg per dosis; CEPH) with an intrauterine applied herbal product (25 ml of EucaComp® PlantaVet containing alcoholic extracts of Calendula officinalis L., Mellissa officinalis L., Origanum majorana L. and Eucalyptus globulus Labill. (EUC)) on the clinical cure of endometritis.
Examinations of 816 cows between 21 and 35 days after calving were performed and cases of clinical endometritis (n = 169) were included. Diagnosis based on a scoring system for vaginal discharge. Study animals were randomly assigned to one of two treatment groups and treated immediately. After excluding animals with incomplete datasets, 136 cows (EUC: n = 61; CEPH: n = 75) remained for the final analysis.
In total, 64% (EUC: 61%, CEPH: 67%) of analysed endometritis cases were considered as clinically cured 14 ± 2 days after the first treatment, 15% stayed uncured after the application of a maximum of two consecutive treatments, leading to an overall clinical cure rate of 85% (EUC: 82%, CEPH: 88%). No statistically difference in clinical cure rates could be observed between both treatment groups nor 14 ± 2 days after the first treatment (p = 0.956) neither regarding the overall cure rate (p = 0.923).
In conclusion, the clinical cure of dairy cows' endometritis after the intrauterine application of the herbal product was non-inferior to the intrauterine application of the antibiotic cephapirin. These results could contribute to reduce the antimicrobial use in the daily veterinary routine treatment of endometritis.
EPrint Type: | Journal paper |
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Keywords: | animal health, dairy cows, antibiotics, uterine diseases, Abacus, FiBL40008, Schaette |
Agrovoc keywords: | Language Value URI English dairy cows http://aims.fao.org/aos/agrovoc/c_26767 English antibiotics http://aims.fao.org/aos/agrovoc/c_492 English uterine diseases http://aims.fao.org/aos/agrovoc/c_15116 |
Subjects: | Animal husbandry > Production systems > Dairy cattle Animal husbandry > Health and welfare |
Research affiliation: | Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Cattle Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal health > Medicinal plants & phytotherapy Switzerland > University of Bern Switzerland > Other organizations Switzerland Germany > Other organizations Germany |
DOI: | 10.1016/j.rvsc.2024.105250 |
Related Links: | https://www.fibl.org/en/themes/projectdatabase/projectitem/project/515 |
Deposited By: | Forschungsinstitut für biologischen Landbau, FiBL |
ID Code: | 53516 |
Deposited On: | 20 Jun 2024 07:06 |
Last Modified: | 20 Jun 2024 07:58 |
Document Language: | English |
Status: | Published |
Refereed: | Peer-reviewed and accepted |
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