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A case-control study on the origin of atypical scrapie in sheep, France.

Fediaevsky, Alexandre; Morignat, Eric; Ducrot, Christian and Calavas, Didier (2009) A case-control study on the origin of atypical scrapie in sheep, France. Emerging Infectious Diseases, pp. 710-718.

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Document available online at: https://hal.inrae.fr/hal-02655325


A matched case-control study (95 cases and 220 controls) was designed to study risk factors for atypical scrapie in sheep in France. We analyzed contacts with animals from other flocks, lambing and feeding practices, and exposure to toxic substances. Data on the prnp genotype were collected for some case and control animals and included in a complementary analysis. Sheep dairy farms had a higher risk for scrapie (odds ratio [OR] 15.1, 95% confidence interval [CI] 3.3-69.7). Lower risk was associated with organic farms (OR 0.15, 95% CI 0.02-1.26), feeding corn silage (OR 0.16, 95% CI 0.05-0.53), and feeding vitamin and mineral supplements (OR 0.6, 95% CI 0.32-1.14). Genetic effects were quantitatively important but only marginally changed estimates of other variables. We did not find any risk factor associated with an infectious origin of scrapie. Atypical scrapie could be a spontaneous disease influenced by genetic and metabolic factors.

EPrint Type:Journal paper
Subjects:"Organics" in general
Research affiliation: France > INRAe - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
ISSN:ISSN: 1080-6040
Related Links:https://hal.inrae.fr/hal-02655325/document
Project ID:HAL-INRAe
Deposited By: PENVERN, Servane
ID Code:40961
Deposited On:12 Aug 2021 10:38
Last Modified:12 Aug 2021 10:38
Document Language:English

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