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A genome wide association study between CNVs and quantitative traits in Brown Swiss cattle

Prinsen, R.T.M.M.; Rossoni, A.; Gredler, B.; Bieber, A.; Bagnato, A. and Strillacci, M.G. (2017) A genome wide association study between CNVs and quantitative traits in Brown Swiss cattle. Livestock Science, 202, pp. 7-12.

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Document available online at: https://www.sciencedirect.com/science/article/abs/pii/S187114131730152X


Summary

Copy Number Variations (CNVs) are DNA sequences of 50 bp up to several Mb long, which can vary in number of copies in comparison with a reference genome. CNVs can be used in association studies to disclose genetic basis of quantitative traits phenotypic variation. Up to date, no genome-wide association study (GWAS) with CNVs and quantitative traits in such a large Brown Swiss population (i.e. with 1116 samples) has been described. The purpose of this study was to perform a GWAS using CNVs with functional, health and productive traits and to asses the impact on farming and breeding practices. The CNV – association studies were performed with the Golden Helix SVS 8.4.4 software using a correlation-trend test model. Genes within significant associated CNVs for each trait were annotated with a GO analysis using the DAVID Bioinformatics Resources 6.7. A total of 56 CNVs were significantly associated with one or more of the eight evaluated traits. The greatest association signals were given by three CNVs on chromosome 12 for the fat yield trait and on BTA23 for udder traits. The associated CNVs overlap with 23 different genes annotated on the Bos taurus genome assembly (UMD3.1).


EPrint Type:Journal paper
Keywords:CNV, GWAS, Brown Swiss, LowInputBreeds, FiBL45009
Agrovoc keywords:
Language
Value
URI
English
cattle
http://aims.fao.org/aos/agrovoc/c_1391
English
genomes
http://aims.fao.org/aos/agrovoc/c_3224
Subjects: Animal husbandry > Production systems > Beef cattle
Animal husbandry > Breeding and genetics
Research affiliation: Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal breeding
European Union > LowInputBreeds > SP 1: Dairy and meat cattle
Italy > Other organizations
Italy > Univ. Milano
Switzerland > Other organizations
DOI:10.1016/j.livsci.2017.05.011
Related Links:https://www.fibl.org/en/themes/projectdatabase/projectitem/project/160.html
Deposited By: Bieber, Anna
ID Code:38547
Deposited On:30 Oct 2020 10:16
Last Modified:03 Aug 2021 07:35
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted

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