Prinsen, R.T.M.M.; Rossoni, A.; Gredler, B.; Bieber, A.; Bagnato, A. and Strillacci, M.G. (2017) A genome wide association study between CNVs and quantitative traits in Brown Swiss cattle. Livestock Science, 202, pp. 7-12.
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Document available online at: https://www.sciencedirect.com/science/article/abs/pii/S187114131730152X
Summary
Copy Number Variations (CNVs) are DNA sequences of 50 bp up to several Mb long, which can vary in number of copies in comparison with a reference genome. CNVs can be used in association studies to disclose genetic basis of quantitative traits phenotypic variation. Up to date, no genome-wide association study (GWAS) with CNVs and quantitative traits in such a large Brown Swiss population (i.e. with 1116 samples) has been described. The purpose of this study was to perform a GWAS using CNVs with functional, health and productive traits and to asses the impact on farming and breeding practices. The CNV – association studies were performed with the Golden Helix SVS 8.4.4 software using a correlation-trend test model. Genes within significant associated CNVs for each trait were annotated with a GO analysis using the DAVID Bioinformatics Resources 6.7. A total of 56 CNVs were significantly associated with one or more of the eight evaluated traits. The greatest association signals were given by three CNVs on chromosome 12 for the fat yield trait and on BTA23 for udder traits. The associated CNVs overlap with 23 different genes annotated on the Bos taurus genome assembly (UMD3.1).
EPrint Type: | Journal paper |
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Keywords: | CNV, GWAS, Brown Swiss, LowInputBreeds, FiBL45009 |
Agrovoc keywords: | Language Value URI English cattle http://aims.fao.org/aos/agrovoc/c_1391 English genomes http://aims.fao.org/aos/agrovoc/c_3224 |
Subjects: | Animal husbandry > Production systems > Beef cattle Animal husbandry > Breeding and genetics |
Research affiliation: | Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal breeding European Union > 7th Framework Programme > LowInputBreeds > SP 1: Dairy and meat cattle Italy > Other organizations Italy > Univ. Milano Switzerland > Other organizations |
DOI: | 10.1016/j.livsci.2017.05.011 |
Related Links: | https://www.fibl.org/en/themes/projectdatabase/projectitem/project/160.html |
Deposited By: | Bieber, Anna |
ID Code: | 38547 |
Deposited On: | 30 Oct 2020 10:16 |
Last Modified: | 03 Aug 2021 07:35 |
Document Language: | English |
Status: | Published |
Refereed: | Peer-reviewed and accepted |
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