Schmidt, Jacob Günther (2022) Effect of induced immunity against red mark syndrome (RMS). [Effekt af induceret immunitet mod rødplet syge (RMS).] .
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Summary
Red mark syndrome (RMS) is a disease affecting rainbow trout under farming conditions. The disease is not lethal but is costly for the fish farmer as the hallmark symptoms of the disease are large, red skin lesions, which often appear in fish of market size. There are currently no good treatment options for this disease.
Due to the apparently benign nature of the disease, we speculated whether early exposure to RMS as fingerlings could result in protective immunity throughout the remainder of the production cycle, thus preventing skin lesions in larger fish and thereby severely reducing the problems associated with RMS.
In order to test this hypothesis, we exposed naïve specific pathogen free (SPF) rainbow trout fingerlings (10-58 g) to RMS by cohabitation. Most of the cohabitants developed clinical signs of RMS during the following three months. The fish were now maintained until 13 months after initiating the first round of cohabitation, at which time they were once again exposed to RMS via cohabitation. This time, non-exposed control fish were also added. The second cohabitation was terminated after 77 days. By then, all negative controls had developed several RMS-lesions, whereas no skin pathology was observed in the pre-exposed fish. All experimental procedures were carried out at 12°C.
The results showed that under the experimental conditions, protective immunity against RMS was induced in fingerlings and lasted for at least 13 months.
This work was part of the project ShelterFish.
Summary translation
Rødpletsyge er en sygdom, der rammer regnbueørreder under opdræt. Sygdommen er ikke dødelig, men er alligevel kostbar for opdrætterne, da sygdommen – som navnet angiver – resulterer i store, røde pletter i huden, og det er desuden oftest fisk i salgsklare størrelser, der rammes. Der eksisterer ingen gode behandlingsmuligheder mod sygdommen.
Da sygdommen øjensynligt er ret mild, spekulerede vi i, hvorvidt man kunne smitte små sættefisk, og om disse i så fald ville være beskyttede mod genudbrud af sygdommen indtil salg.
For at teste denne hypotese, smittede vi sættefisk (10-58 g) ved at sætte dem sammen med RMS-ramte fisk (kohabitering). De fleste af fiskene udviklede RMS-symptomer i løbet af de følgende tre måneder. Fiskene blev 13 måneder efter første kohabitering endnu engang kohabiteret med RMS-ramte fisk. Denne gang blev naive kontrolfisk også medtaget. Denne anden kohabitering blev afsluttet efter 77 dage. På dette tidspunkt havde alle de naive kontrolfisk udviklet adskillige RMS-hudlæsioner, hvorimod der ingen hudforandringer var at se hos de fisk, der tidligere var blevet smittet som sættefisk. Alle forsøg blev udført ved 12°C.
Konklusionen på forsøgene var altså, at beskyttende immunitet kunne induceres i sættefisk under de eksperimentelle forhold, og at disse fisk var beskyttede mod genudbrud af sygdommen i mindst 13 måneder.
Dette arbejde blev udført som en del af projektet ShelterFish.
| EPrint Type: | Report |
|---|---|
| Keywords: | Rainbow trout, red mark disease, RMS, natural immunity |
| Agrovoc keywords: | Language Value URI English UNSPECIFIED UNSPECIFIED |
| Subjects: | Animal husbandry > Health and welfare |
| Research affiliation: | Denmark > Organic RDD 4 > ShelterFish |
| Deposited By: | Jokumsen, Senior Advisory Scientist Alfred |
| ID Code: | 43266 |
| Deposited On: | 20 Jan 2022 15:46 |
| Last Modified: | 20 Jan 2022 15:46 |
| Document Language: | English |
| Status: | Submitted |
| Refereed: | Not peer-reviewed |
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