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Interactions of tagatose with the sugar metabolism are responsible for Phytophthora infestans growth inhibition

Corneo, Paola Elisa; Nesler, Andrea; Liotti, Cesare; Chahed, Abdessalem; Vrhovsek, U; Pertot, Ilaria and Perazzolli, Michele (2021) Interactions of tagatose with the sugar metabolism are responsible for Phytophthora infestans growth inhibition. Microbiological Research, 247, p. 126724.

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Document available online at: https://www.sciencedirect.com/science/article/pii/S0944501321000306?via%3Dihub


Summary

Tagatose is a rare sugar metabolised by a limited number of microorganisms that inhibits a large spectrum of phytopathogens. In particular, tagatose inhibited Phytophthora infestans growth and negatively affected mitochondrial processes. However, the possible effects of tagatose on P. infestans metabolism have not yet been investigated. The aim of this study was to analyse the impact of this rare sugar on the sugar metabolism in P. infestans, in order to better understand its mode of action. Tagatose inhibited the growth of P. infestans with a precise reprogramming of the carbohydrate metabolism that involved a decrease of glucose, glucose-1-phosphate and mannose content and β-glucosidase activity. The combination of tagatose with common sugars led to three different responses and highlighted antagonistic interactions. In particular, glucose partially attenuated the inhibitory effects of tagatose, while fructose fully impaired tagatose-mediated growth inhibition and metabolite changes. Moreover, sucrose did not attenuate tagatose effects, suggesting that the inhibition of sucrose catabolism and the alteration of glucose-related pathways contributed to the growth inhibition caused by tagatose to P. infestans. The interactions of tagatose with the common sugar metabolism were found to be a key mode of action against P. infestans growth, which may represent the basis for the further development of tagatose as an eco-friendly fungicide.


EPrint Type:Journal paper
Keywords:Rare sugar, Tagatose, Phytophthora infestans, Sugar metabolism
Agrovoc keywords:
Language
Value
URI
English
Phytophthora infestans
http://aims.fao.org/aos/agrovoc/c_27304
Subjects: Crop husbandry > Crop health, quality, protection
Research affiliation:Belgium
European Union > Horizon 2020 > RELACS
France > Other organizations
Italy > Other organizations
H2020 or FP7 Grant Agreement Number:773431
DOI:10.1016/j.micres.2021.126724
Deposited By: Perazzolli, Prof. Michele
ID Code:40143
Deposited On:12 Jul 2021 11:45
Last Modified:12 Jul 2021 11:45
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted

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