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Genetic and genomic analysis of hyperthelia in Brown Swiss cattle

Butty, A.M.; Frischknecht, M.; Gredler, B.; Baes, C.; Neuenschwander, S.; Moll, J.; Bieber, A. and Seefried, F.R. (2017) Genetic and genomic analysis of hyperthelia in Brown Swiss cattle. Journal of Dairy Science, 100, pp. 402-411.

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Summary

Supernumerary teats (SNT) are any abnormal teats found on a calf in addition to the usual and functional 4 teats. The presence of SNT has also been termed “hyperthelia” since the end of the 19th century. Supernumerary teats can act as an incubator for bacteria, infecting the whole udder, and can interfere with the positioning of the milking machine, and consequently, have economic relevance. Different types of SNT are observed at different positions on the udder. Caudal teats are in the rear, ramal teats are attached to another teat, and intercalary teats are found between 2 regular teats. Not all teats are equally developed; some are completely functional but most are rudimentary and not attached to any mammary gland tissue. Recently, different studies showed the poly/oligogenic character of these malformations in cattle as well as in other mammalian species. The objective of this study was to analyze the genetic architecture and incidence of hyperthelia in Swiss Brown Swiss cattle using both traditional genetic evaluation as well as imputed whole genome sequence variant information. First, phenotypes collected over the last 20 yr were used together with pedigree information for estimation of genetic variance. Second, breeding values of Brown Swiss bulls were estimated applying the BLUP algorithm. The BLUP-EBV were deregressed and used as phenotypes in genome-wide association studies. The gene LGR5 on chromosome 5 was identified as a candidate for the presence of SNT. Using alternative trait coding, genomic regions on chromosome 17 and 20 were also identified as being involved in the development of SNT with their own supernumerary mammary gland tissue. Implementing knowledge gained in this study as a routine application allows a more accurate evaluation of the trait and reduction of SNT prevalence in the Swiss Brown Swiss cattle population.


EPrint Type:Journal paper
Keywords:dairy cattle hyperthelia supernumerary teats genome-wide association
Agrovoc keywords:
Language
Value
URI
English
UNSPECIFIED
UNSPECIFIED
Subjects: Animal husbandry > Production systems > Dairy cattle
Animal husbandry > Breeding and genetics
Research affiliation: Canada
Canada > University of Guelph, Ontario
Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal breeding
Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal welfare & housing
Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland
Switzerland
Switzerland > Other organizations
Deposited By: Bieber, Anna
ID Code:38368
Deposited On:21 Sep 2020 16:54
Last Modified:28 Jul 2021 11:30
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted

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