Bouwman, Aniek C.; Daetwyler, Hans D.; Chamberlain, Amanda J.; Hurtado Ponce, Carla; Sargolzaei, Mehdi; Schenkel, Flavio S.; Sahana, Goutam; Govignon-Gion, Armelle; Boitard, Simon; Dolezal, Marlies; Pausch, Hubert; Brøndum, Rasmus F.; Bowman, Phil J.; Thomsen, Bo; Guldbrandtsen, Bernt; Lund, Morgns S.; Servin, Bertrand; Garrick, Dorian J.; Reecy, James; Vilkki, Johanna; Bagnato, Alessandro; Wang, Min; Hoff, Jesse L.; Schnabel, Robert D.; Taylor, Jeremy F.; Vinkhuyzen, Anna A. E.; Panitz, Frank; Bendixen, Christian; Holm, Lars-Erik; Gredler, Birgit; Hozé, Chris; Boussaha, Mekki; Sanchez, Marie-Pierre; Rocha, Dominique; Capitan, Aurelien; Tribout, Thierry; Barbat, Anne; Croiseau, Pascal; Drögemüller, Cord; Jagannathan, Vidhya; Vander Jagt, Christy; Bieber, Anna; Purfield, Deidre C.; Berry, Donagh P.; Emmerling, Reiner; Götz, Kay-Uwe; Frischknecht, Mirjam; Russ, Ingolf; Sölkner, Johann; Van Tassel, Curtis P.; Fries, Ruedi; Stothard, Paul; Veerkamp, Roel F.; Boichard, Didier; Goddard, Mike E. and Hayes, Ben J. (2018) Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals. Nature Genetics, 50, pp. 362-367.
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Document available online at: https://www.nature.com/articles/s41588-018-0056-5
Summary
Stature is affected by many polymorphisms of small effect in humans1. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10−8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP–seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
| EPrint Type: | Journal paper |
|---|---|
| Keywords: | cattle, animal breeding |
| Agrovoc keywords: | Language Value URI English cattle http://aims.fao.org/aos/agrovoc/c_1391 |
| Subjects: | Animal husbandry > Production systems > Dairy cattle Animal husbandry > Production systems > Beef cattle Animal husbandry > Breeding and genetics |
| Research affiliation: | Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal breeding |
| Deposited By: | Bieber, Anna |
| ID Code: | 35102 |
| Deposited On: | 20 Mar 2019 16:51 |
| Last Modified: | 28 Jul 2021 11:29 |
| Document Language: | English |
| Status: | Published |
| Refereed: | Peer-reviewed and accepted |
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