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Antimicrobial effect of dietary nitrate in weaning piglets challenged or not with Salmonella enterica serovar typhimurium

Modesto, Monica; D'Aimmo, Maria Rosaria; Stefanini, Ilaria; Mazzoni, Maurizio; Bosi, Paolo and Biavati, Bruno (2008) Antimicrobial effect of dietary nitrate in weaning piglets challenged or not with Salmonella enterica serovar typhimurium. Poster at: Cultivating the Future Based on Science: 2nd Conference of the International Society of Organic Agriculture Research ISOFAR, Modena, Italy, June 18-20, 2008.

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The maintenance of a beneficial bacteria balance in the gut is important to increase the animal’s resistance to diseases. Nitrite may kill gut pathogens representing a non-immune defence mechanism. Nitrite can be derived from dietary nitrate that is reduced under the acidic conditions of the oral cavity.
An in vivo study was designed in order to establish the antimicrobial effects of dietary nitrate on the gut microbiota and on the health of 96 weaning piglets. The pigs were fed a diet containing high levels of nitrate (15 mg/kg feed and 150 mg/kg feed) and then challenged with Salmonella enterica serovar typhimurium. Changes of the intestinal microbiota composition were assessed by analysing the stomach and jejunum contents from all the pigs.
Results showed that nitrate only affected the population levels of Lactic Acid Bacteria (LAB) in both segments. Pigs challenged with Salmonella showed a reduction in the levels of E. coli and clostridia in the jejunum suggesting a mechanism of competition for niches or for active sites. The time from challenge significantly decreased the number of LAB in stomach and jejunum. It also decreased the population density of clostridia in the stomach. The supplementation of feedstuff with high dietary nitrate intake contemporarily to the challenge with Salmonella did not affect the degree of ulceration in the pigs.

EPrint Type:Conference paper, poster, etc.
Type of presentation:Poster
Keywords:nitrates, intestinal microbiota, weaning piglets, Salmonella
Subjects: Animal husbandry > Production systems > Pigs
Animal husbandry > Health and welfare
Research affiliation: International Conferences > 2008: IFOAM OWC: Research Track / ISOFAR > 3.4 Animal health and nutrition – non ruminants
Italy > Univ. Bologna
Deposited By: Modesto, Doc Monica
ID Code:11817
Deposited On:07 Oct 2008
Last Modified:12 Apr 2010 07:36
Document Language:English
Refereed:Peer-reviewed and accepted
Additional Publishing Information:This paper is published in the conference proceedings:
Neuhoff, Daniel; Halberg, Niels; Alfldi, Thomas; Lockeretz, William; Thommen, Andreas; Rasmussen, Ilse A.; Hermansen, John; Vaarst, Mette; Lck, Lorna; Carporali, Fabio; Jensen, Henning Hgh; Migliorini, Paola and Willer, Helga, Eds. (2008) .Cultivating the Future Based on Science. Proceedings of the Second Scientific Conference of the International Society of Organic Agriculture Research (ISOFAR), held at the 16th IFOAM Organic World Congress in Cooperation with the International Federation of Organic Agriculture Movements (IFOAM) and the Consorzio ModenaBio, 18 . 20 June 2008 in Modena, Italy.. International Society of Organic Agriculture Research (ISOFAR), c/o IOL, DE-Bonn, Research Institute of Organic Agriculture FiBL, CH-Frick. http://orgprints.org/13672 and http://orgprints.org/13674

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