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Genome-wide association study in Brown Swiss for fertility traits based on sequence data

Frischknecht, M.; Bapst, B.; Flury, C.; Seefried, F.R.; Signer-Hasler, H.; Garrick, D.; Stricker, C.; Intergenomics, Consortium; Bagnato, A.; Bieber, A.; Fries, R.; Russ, I.; Sölkner, J. and Gredler, B. (2016) Genome-wide association study in Brown Swiss for fertility traits based on sequence data. In: Book of Abstracts of the 67th Annual Meeting of the European Federation of Animal Science, 29 August - 2 September 2016, Belfast, UK, p. 111.

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Summary

Fertility in dairy cattle has declined continuously during the last years. In Switzerland low fertility is one of the most important culling reason. Therefore this trait complex is of great economic importance. But fertility traits are functional traits with low heritabilities. We performed GWAS in Brown Swiss and Holstein cattle for the fertility traits: non-return rate after 56 days in heifers (NRH) and cows (NRC); days between first and last insemination in heifers (FLIH) and cows (FLIC); and days to first service (DFS). We used deregressed breeding values as input phenotypes and imputed whole-genome sequence dosages as genotypes. In Holstein (2,336 to 3,257 individuals) we could not identify any significant region for any of the investigated traits. For Brown Swiss cattle (1,392 to 3,278 individuals) however we could identify a QTL on BTA 17 for NRH and FLIH. This locus also showed a suggestive association with NRC and FLIC. The region significantly associated to NRH and FLIH comprises 27 genes. Among the associated variants two non-synonymous variants in the genes GAS2L and ASCC2 could be identified. These two variants could be potentially causative ariants.


EPrint Type:Conference paper, poster, etc.
Type of presentation:Poster
Keywords:dairy cattle, animal breeding, fertility
Agrovoc keywords:
LanguageValueURI
Englishdairy cattlehttp://aims.fao.org/aos/agrovoc/c_2108
Englishfertilityhttp://aims.fao.org/aos/agrovoc/c_2862
Subjects: Animal husbandry > Production systems > Dairy cattle
Animal husbandry > Breeding and genetics
Animal husbandry > Health and welfare
Research affiliation: Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Animal breeding
Switzerland > FiBL - Research Institute of Organic Agriculture Switzerland > Animal > Cattle
Deposited By: Bieber, Anna
ID Code:38678
Deposited On:02 Dec 2020 09:45
Last Modified:02 Dec 2020 09:46
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted

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