6525 1 archive 3935 disk0/00/00/65/25 2006-01-21 2009-08-20 14:29:09 2009-08-20 14:29:09 project show 0 fr-inra 287800 Alternatives to chemical drugs in the control of gastrointestinal parasitisim in small ruminants : role of condensed tannins. fr-inra 0 115000 172800 17 UMR 1225 INRA DGER ENVT 23 chemin des Capelles 31076 TOULOUSE 2007-12-31 2005-01-01 FALSE Hoste Hervé Dr 5mall 7animalhealth parasitism, tannins, nematodes, ruminants, anthelmintic effects Recent results have shown that tanniferous plants might represent an alternative option to chemical drugs to control parasitic nematodes of the gastrointestinal tract in small ruminants since some anthelmintic activity has been associated with the consumption of the plants. The 2 main objectives of the project are : 1 to understand the mechanisms explaining the activity of tannin rich plants against nematode parasites of sheep and goats 2 to identify novel natural resources to exploit for non chemical control of parasite in various farming systems, including organic farming. In particular, the project focus on potential industrial agroressources In vitro and in vivo assays on parasites and on infected animals to measure the anthelmintic effects, methods of histology and electron microscopy to examine the lesions induced by tannin to the worms, and biochemical analysis of plant extracts or industrial agroressources have been used. The project is still in progress. However, the current results indicate that : - condensed tannins interfere both with the main function and structure of third stage larvae - some industrial resources for tannins have been identified INRA none