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Exploring hair cortisone concentration as a novel tool to assess chronic stress in sheep With tick-borne Fever

Stubsjøen, Solveig Marie; Sørheim, Kristin; Chincarino, Matteo; Bolin, Jon; Brunberg, Emma; Fuchs, Boris; Palme, Rupert and Grøva, Lise (2018) Exploring hair cortisone concentration as a novel tool to assess chronic stress in sheep With tick-borne Fever. Small Ruminant Research, 164 (2018), pp. 110-119.

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Summary

Tick-borne fever (TBF), caused by the bacterium Anaplasma phagocytophilum and transmitted by the tick Ixodes ricinus, has considerable consequences for animal welfare and economy in the sheep industry. Non-invasive, objective methods to quantify chronic stress are needed in order to evaluate the welfare impact of disease. The aim of this study was 1) to evaluate hair cortisol (HC) and hair cortisone (HCn) as biomarkers of chronic stress in sheep with TBF and 2) to test whether there was an association between the development of TBF and concentrations of HC, HCn and faecal cortisol metabolites (FCM) and body weight. The experiment took place in an area with a high prevalence of TBF, and thirty lambs were used in the study. Wool samples were collected in Week 0, in Week 3 (before turn out on homeland spring pasture), in Week 6 (before turn out on summer rangeland pasture) and at the end of the summer (Week 15). Faecal samples were collected every week (ie. Week 0–6 and Week 15). Symptoms of TBF developed in 15 lambs, of which all recovered from the disease after treatment with antibiotics. HC levels decreased progressively, and significantly, between Week 0, 3, 6 and 15(p < 0.001), while HCn only decreased from Week 0 to Week 3 (p < 0.001) and then remained stable between Week 3–15. FCM increased between Week 0 and 5 (p=0.027), and a significant association was found between increased FCM levels in Week 5 and lambs developing clinical signs of TBF (p=0.022). We also found an association between lambs developing clinical signs of TBF and elevated HCn levels in Week 6 (p=0.013). A slightly lower weight gain at later time points (Week 6 and 15) were found in the affected lambs compared to clinically healthy lambs. Our results indicate local production and/or metabolism of glucocorticoids in the hair follicles. This study strengthens our previous finding of a potential merit of hair cortisone as a biomarker of chronic stress in sheep.


EPrint Type:Journal paper
Agrovoc keywords:
LanguageValueURI
Englishanimal welfarehttp://aims.fao.org/aos/agrovoc/c_443
EnglishChronic stressUNSPECIFIED
EnglishHair glucocorticoidsUNSPECIFIED
Englishsheephttp://aims.fao.org/aos/agrovoc/c_7030
EnglishTick borne feverUNSPECIFIED
Subjects: Animal husbandry > Production systems > Sheep and goats
Animal husbandry > Health and welfare
Research affiliation: Norway > NVI - National Veterinary Institute
Norway > NORSØK - Norwegian Centre for Organic Agriculture
Deposited By: Sørheim, Kristin Marie
ID Code:35030
Deposited On:19 Mar 2019 10:23
Last Modified:19 Mar 2019 10:23
Document Language:English
Status:Published
Refereed:Peer-reviewed and accepted

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